Detalhe da pesquisa
1.
Allosteric regulation of menaquinone (vitamin K2) biosynthesis in the human pathogen Mycobacterium tuberculosis.
J Biol Chem
; 295(12): 3759-3770, 2020 03 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-32029475
2.
The active site of the Mycobacterium tuberculosis branched-chain amino acid biosynthesis enzyme dihydroxyacid dehydratase contains a 2Fe-2S cluster.
J Biol Chem
; 294(35): 13158-13170, 2019 08 30.
Artigo
em Inglês
| MEDLINE | ID: mdl-31315931
3.
Regulation of human 4-hydroxy-2-oxoglutarate aldolase by pyruvate and α-ketoglutarate: implications for primary hyperoxaluria type-3.
Biochem J
; 476(21): 3369-3383, 2019 11 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-31696211
4.
Stress control for a well-structured life.
J Biol Chem
; 293(16): 5806-5807, 2018 04 20.
Artigo
em Inglês
| MEDLINE | ID: mdl-29678889
5.
Group A Streptococcus T Antigens Have a Highly Conserved Structure Concealed under a Heterogeneous Surface That Has Implications for Vaccine Design.
Infect Immun
; 87(6)2019 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-30936156
6.
Mechanistic insights into F420-dependent glucose-6-phosphate dehydrogenase using isotope effects and substrate inhibition studies.
Biochim Biophys Acta Proteins Proteom
; 1866(2): 387-395, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28807886
7.
Anthranilate phosphoribosyltransferase: Binding determinants for 5'-phospho-alpha-d-ribosyl-1'-pyrophosphate (PRPP) and the implications for inhibitor design.
Biochim Biophys Acta Proteins Proteom
; 1866(2): 264-274, 2018 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-28844746
8.
A functional role of Rv1738 in Mycobacterium tuberculosis persistence suggested by racemic protein crystallography.
Proc Natl Acad Sci U S A
; 112(14): 4310-5, 2015 Apr 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-25831534
9.
Elongation of the Poly-γ-glutamate Tail of F420 Requires Both Domains of the F420:γ-Glutamyl Ligase (FbiB) of Mycobacterium tuberculosis.
J Biol Chem
; 291(13): 6882-94, 2016 Mar 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-26861878
10.
The Structure of the Transcriptional Repressor KstR in Complex with CoA Thioester Cholesterol Metabolites Sheds Light on the Regulation of Cholesterol Catabolism in Mycobacterium tuberculosis.
J Biol Chem
; 291(14): 7256-66, 2016 Apr 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26858250
11.
Autocatalytically generated Thr-Gln ester bond cross-links stabilize the repetitive Ig-domain shaft of a bacterial cell surface adhesin.
Proc Natl Acad Sci U S A
; 111(4): 1367-72, 2014 Jan 28.
Artigo
em Inglês
| MEDLINE | ID: mdl-24344302
12.
Investigating the Reaction Mechanism of F420-Dependent Glucose-6-phosphate Dehydrogenase from Mycobacterium tuberculosis: Kinetic Analysis of the Wild-Type and Mutant Enzymes.
Biochemistry
; 55(39): 5566-5577, 2016 Oct 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27603793
13.
Complex Formation between Two Biosynthetic Enzymes Modifies the Allosteric Regulatory Properties of Both: AN EXAMPLE OF MOLECULAR SYMBIOSIS.
J Biol Chem
; 290(29): 18187-18198, 2015 Jul 17.
Artigo
em Inglês
| MEDLINE | ID: mdl-26032422
14.
Synthesis and structural insight into ESX-1 Substrate Protein C, an immunodominant Mycobacterium tuberculosis-secreted antigen.
Biopolymers
; 106(3): 267-74, 2016 May.
Artigo
em Inglês
| MEDLINE | ID: mdl-26999334
15.
Radiation Damage and Racemic Protein Crystallography Reveal the Unique Structure of the GASA/Snakin Protein Superfamily.
Angew Chem Int Ed Engl
; 55(28): 7930-3, 2016 07 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-27145301
16.
Intramolecular isopeptide bonds: protein crosslinks built for stress?
Trends Biochem Sci
; 36(4): 229-37, 2011 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-21055949
17.
Structures of Mycobacterium tuberculosis Anthranilate Phosphoribosyltransferase Variants Reveal the Conformational Changes That Facilitate Delivery of the Substrate to the Active Site.
Biochemistry
; 54(39): 6082-92, 2015 Oct 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-26356348
18.
Use of a "silver bullet" to resolve crystal lattice dislocation disorder: a cobalamin complex of Δ1-pyrroline-5-carboxylate dehydrogenase from Mycobacterium tuberculosis.
J Struct Biol
; 189(2): 153-7, 2015 Feb.
Artigo
em Inglês
| MEDLINE | ID: mdl-25557497
19.
Structural model for covalent adhesion of the Streptococcus pyogenes pilus through a thioester bond.
J Biol Chem
; 289(1): 177-89, 2014 Jan 03.
Artigo
em Inglês
| MEDLINE | ID: mdl-24220033
20.
A covalent adduct of MbtN, an acyl-ACP dehydrogenase from Mycobacterium tuberculosis, reveals an unusual acyl-binding pocket.
Acta Crystallogr D Biol Crystallogr
; 71(Pt 4): 862-72, 2015 Apr.
Artigo
em Inglês
| MEDLINE | ID: mdl-25849397